EVALUATING RESEARCH METHODS FOR DMR REPORTING USING THE BALANCED SCORECARD APPROACH
DOI:
https://doi.org/10.34218/IJCET_16_03_024Keywords:
Dementia Questionnaire (DMR), Intellectual Disabilities, Methylation Patterns, Imprinted Genes, Epigenetics, Fetal Alcohol Syndrome (FAS), Imprinting DisordersAbstract
Introduction: The Dementia Questionnaire for Mentally Ill People (DMR) is a specialized assessment tool designed to detect dementia in individuals with intellectual disabilities, with a particular focus on those with Down syndrome (DS). First introduced in the Netherlands in 1980, the DMR was developed to offer a consistent and reliable method for the early identification of dementia in both individuals with and without intellectual impairments.The DMR questionnaire is composed of eight subscales, each evaluating a specific cognitive or behavioral function: short-term memory, long-term memory, spatial and temporal orientation, speech skills, practical skills, mood, activity and interests, and behavioral disturbances. It utilizes two main scoring systems: the Summary of Cognitive Scores (SCS), which assesses memory and orientation, and the Summary of Social Scores (SOS), which measures communication and social interactions. To aid in dementia diagnosis, established cut-off scores help distinguish between single-time evaluations and ongoing changes over time. Research significance: By examining the various research methods used in DMR reporting, this study provides valuable insights into the advantages and limitations of different approaches, including longitudinal cohort studies, cross-sectional studies, genetic studies, animal models, and intervention programs. Understanding the role of these methods in DMR analysis is critical for advancing epigenetic research, improving clinical diagnostics, and developing treatment strategies.A key aspect of the significance of this study lies in its relevance to dementia research, intellectual disabilities, and fetal alcohol syndrome (FAS). By examining DNA methylation patterns and their influence on gene expression, this research helps identify biomarkers that could facilitate early diagnosis and targeted therapies. In addition, this study provides important insights into imprinting disorders such as Temple syndrome (TS14) and Kagami-Okata syndrome (KOS14), both of which are associated with abnormal methylation at DMRs. Methology: The alternative options for Longitudinal Cohort Studies, Animal Model Studies, Cross-Sectional Surveys, Genetic Studies, Intervention Programs. The evaluation criteria consist of Comprehensive Data Collection, Diverse Population Insights, Ethical Concerns, Limited Generalizability. Result: According to the results, Cross-Sectional Surveys was ranked highest, while Genetic Studies was ranked lowest. Conclusion: Cross-Sectional Surveys has the highest value for DMR Reporting according to the MOORA approach.
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